846 research outputs found
The influence of calibration curve construction and composition on the accuracy and precision of radiocarbon wiggle-matching of tree rings, illustrated by Southern Hemisphere atmospheric data sets from ad 1500â1950
This research investigates two factors influencing the ability of tree-ring data to provide accurate 14C calibration information: the fitness and rigor of the statistical model used to combine the data into a curve; and the accuracy, precision and reproducibility of the component 14C data sets. It presents a new Bayesian spline method for calibration curve construction and tests it on extant and new Southern Hemisphere (SH) data sets (also examining their dendrochronology and pretreatment) for the post-Little Ice Age (LIA) interval AD 1500â1950. The new method of construction allows calculation of component data offsets, permitting identification of laboratory and geographic biases. Application of the new method to the 10 suitable SH 14C data sets suggests that individual offset ranges for component data sets appear to be in the region of ± 10 yr. Data sets with individual offsets larger than this need to be carefully assessed before selection for calibration purposes. We identify a potential geographical offset associated with the Southern Ocean (high latitude) Campbell Island data. We test the new methodology for wiggle-matching short tree-ring sequences and use an OxCal simulation to assess the likely precision obtainable by wiggle-matching in the post-LIA interval
Simulations of cubic-tetragonal ferroelastics
We study domain patterns in cubic-tetragonal ferroelastics by solving
numerically equations of motion derived from a Landau model of the phase
transition, including dissipative stresses. Our system sizes, of up to 256^3
points, are large enough to reveal many structures observed experimentally.
Most patterns found at late stages in the relaxation are multiply banded; all
three tetragonal variants appear, but inequivalently. Two of the variants form
broad primary bands; the third intrudes into the others to form narrow
secondary bands with the hosts. On colliding with walls between the primary
variants, the third either terminates or forms a chevron. The multipy banded
patterns, with the two domain sizes, the chevrons and the terminations, are
seen in the microscopy of zirconia and other cubic-tetragonal ferroelastics. We
examine also transient structures obtained much earlier in the relaxation;
these show the above features and others also observed in experiment.Comment: 7 pages, 6 colour figures not embedded in text. Major revisions in
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Specific refolding pathway of viscumin A chain in membrane-like medium reveals a possible mechanism of toxin entry into cell
How is a water-soluble globular protein able to spontaneously cross a cellular membrane? It is commonly accepted that it undergoes significant structural rearrangements on the lipid-water interface, thus acquiring membrane binding and penetration ability. In this study molecular dynamics (MD) simulations have been used to explore large-scale conformational changes of the globular viscumin A chain in a complex environment - comprising urea and chloroform/methanol (CHCl /MeOH) mixture. Being well-packed in aqueous solution, viscumin A undergoes global structural rearrangements in both organic media. In urea, the protein is "swelling" and gradually loses its long-distance contacts, thus resembling the "molten globule" state. In CHCl /MeOH, viscumin A is in effect turned "inside out". This is accompanied with strengthening of the secondary structure and surface exposure of hydrophobic epitopes originally buried inside the globule. Resulting solvent-adapted models were further subjected to Monte Carlo simulations with an implicit hydrophobic slab membrane. In contrast to only a few point surface contacts in water and two short regions with weak protein-lipid interactions in urea, MD-derived structures in CHCl /MeOH reveal multiple determinants of membrane interaction. Consequently it is now possible to propose a specific pathway for the structural adaptation of viscumin A with respect to the cell membrane - a probable first step of its translocation into cytoplasmic targets
Charged Higgs Observability Through Associated Production With W at a Muon Collider
The observability of a charged Higgs boson produced in association with a W
boson at future muon colliders is studied. The analysis is performed within the
MSSM framework. The charged Higgs is assumed to decay to tb and a fully
hadronic final state is analyzed, i.e., mu+mu- \rightarrow H\pmW\mp \rightarrow
tbW \rightarrow WbbW \rightarrow jjjjbb. The main background is tt production
in fully hadronic final state which is an irreducible background with very
similar kinematic features. It is shown that although the discovery potential
is almost the same for a charged Higgs mass in the range 200 GeV < mH\pm < 400
GeV, the signal significance is about 1sigma for tanbeta = 50 at integrated
luminosity of 50 fb-1. The signal rate is well above that at e+e- linear
colliders with the same center of mass energy and enough data (O(1 ab-1)) will
provide the same discovery potential for all heavy charged Higgs masses up to
mH\pm \sim 400 GeV, however, the muon collider cannot add anything to the LHC
findings.Comment: 18 pages, 11 figure
The Microarcsecond Sky and Cosmic Turbulence
Radio waves are imprinted with propagation effects from ionized media through
which they pass. Owing to electron density fluctuations, compact sources
(pulsars, masers, and compact extragalactic sources) can display a wide variety
of scattering effects. These scattering effects, particularly interstellar
scintillation, can be exploited to provide *superresolution*, with achievable
angular resolutions (<~ 1 microarcsecond) far in excess of what can be obtained
by very long baseline interferometry on terrestrial baselines. Scattering
effects also provide a powerful sub-AU probe of the microphysics of the
interstellar medium, potentially to spatial scales smaller than 100 km, as well
as a tracer of the Galactic distribution of energy input into the interstellar
medium through a variety of integrated measures. Coupled with future gamma-ray
observations, SKA observations also may provide a means of detecting fainter
compact gamma-ray sources. Though it is not yet clear that propagation effects
due to the intergalactic medium are significant, the SKA will either detect or
place stringent constraints on intergalactic scattering.Comment: 20 pages, 8 figures in 8 PostScript files, to appear in "Science with
the Square Kilometer Array," eds. C. Carilli and S. Rawlings, New Astronomy
Reviews (Elsevier: Amsterdam
A gene variant near ATM is significantly associated with metformin treatment response In type 2 diabetes: A replication and meta-analysis of five cohorts
_Aims/hypothesis:_ In this study we aimed to replicate the previously reported association between the glycaemic response to metformin and the SNP rs11212617 at a locus that includes the ataxia telangiectasia mutated (ATM) gene in multiple additional populations.
_Methods:_ Incident users of metformin selected from the Diabetes Care System West-Friesland (DCS, n=929) and the Rotterdam Study (n=182) from the Netherlands, and the CARDS Trial (n=254) from the UK were genotyped for rs11212617 and tested for an association with both HbA1c reduction and treatment success, defined as the ability to reach the treatment target of an HbA1c â€7 % (53 mmol/mol). Finally, a meta-analysis including data from literature was performed.
_Results:_ In the DCS cohort, we observed an association between rs11212617 genotype and treatment success on metformin (OR 1.27, 95% CI 1.03, 1.58, p=0.028); in the smaller Rotterdam Study cohort, a numerically similar but non-significant trend was observed (OR 1.45, 95% CI 0.87, 2.39, p=0.15); while in the CARDS cohort there was no significant association. In meta-analyses of these three cohorts separately or combined with the previously published cohorts, rs11212617 genotype is associated with metformin treatment success (OR 1.24, 95% CI 1.04, 1.49, p=0.016 and OR 1.25, 95% CI 1.33, 1.38, p=7.8Ă10-6, respectively).
_ Conclusions/inte
SHCal20 Southern Hemisphere Calibration, 0â55,000 Years cal BP
Early researchers of radiocarbon levels in Southern Hemisphere tree rings identified a variable North-South hemispheric offset, necessitating construction of a separate radiocarbon calibration curve for the South. We present here SHCal20, a revised calibration curve from 0â55,000 cal BP, based upon SHCal13 and fortified by the addition of 14 new tree-ring data sets in the 2140â0, 3520â3453, 3608â3590 and 13,140â11,375 cal BP time intervals. We detail the statistical approaches used for curve construction and present recommendations for the use of the Northern Hemisphere curve (IntCal20), the Southern Hemisphere curve (SHCal20) and suggest where application of an equal mixture of the curves might be more appropriate. Using our Bayesian spline with errors-in-variables methodology, and based upon a comparison of Southern Hemisphere tree-ring data compared with contemporaneous Northern Hemisphere data, we estimate the mean Southern Hemisphere offset to be 36 ± 27 14C yrs older
Search for displaced vertices arising from decays of new heavy particles in 7 TeV pp collisions at ATLAS
We present the results of a search for new, heavy particles that decay at a
significant distance from their production point into a final state containing
charged hadrons in association with a high-momentum muon. The search is
conducted in a pp-collision data sample with a center-of-mass energy of 7 TeV
and an integrated luminosity of 33 pb^-1 collected in 2010 by the ATLAS
detector operating at the Large Hadron Collider. Production of such particles
is expected in various scenarios of physics beyond the standard model. We
observe no signal and place limits on the production cross-section of
supersymmetric particles in an R-parity-violating scenario as a function of the
neutralino lifetime. Limits are presented for different squark and neutralino
masses, enabling extension of the limits to a variety of other models.Comment: 8 pages plus author list (20 pages total), 8 figures, 1 table, final
version to appear in Physics Letters
Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment
This paper describes an analysis of the angular distribution of W->enu and
W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with
the ATLAS detector at the LHC in 2010, corresponding to an integrated
luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and
the missing transverse energy, the W decay angular distribution projected onto
the transverse plane is obtained and analysed in terms of helicity fractions
f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV
and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw
> 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour,
are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017
+/- 0.030, where the first uncertainties are statistical, and the second
include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables,
revised author list, matches European Journal of Physics C versio
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